LPP is a chronic inflammatory disease that leads to permanent hair loss. LPP is the prototypical lymphocytic cicatricial alopecia (Lepe and Salazar, 2017), characterized by a chronic lymphocytic inflammation that leads to destruction of hair follicles, perifollicular fibrosis and sebaceous gland atrophy, leading to scarring alopecia.
LPP is a rare condition classified as orphan disease (ORPHA:525).
There are no products authorised for LPP treatment and no available therapeutic options that cure the disease exist.
Even if the pathogenesis of LPP is not yet completely understood, recent evidences (Harries et al, 2013 and 2018) show that LPP is characterized by immune privilege collapse on the hair follicle’s epithelial stem cell niche, immune cell attack, epithelial-mesenchymal transition (EMT).